Command R+, Mistral Large 2, and Qwen 3 72B Instruct are all large open-weights models from 2024–2025 that target enterprise-grade instruction-following, RAG, and reasoning workloads. The key differentiators are licensing constraints, multilingual depth, and inference cost. Command R+ is Cohere's 104-billion-parameter model, released April 2024 with 131K context. Its design emphasizes enterprise RAG pipelines and multi-step tool use, backed by Cohere's own retrieval evaluation tooling. The CC-BY-NC license is the most restrictive of the three — commercial production deployments are expected to use Cohere's own API, limiting flexibility on provider choice. Mistral Large 2 is Mistral AI's second-generation large model, released in 2024. It delivers strong multilingual coverage across European languages, solid coding performance, and competitive reasoning benchmarks for its parameter class. Mistral's licensing on Large 2 allows research and certain commercial use; verify current terms, as Mistral's licensing has evolved. Provider availability on Together, DeepInfra, and Fireworks makes it easy to benchmark across multiple cost tiers. Qwen 3 72B Instruct from Alibaba is the flagship of the Qwen 3 family with particularly deep CJK multilingual coverage and strong general reasoning benchmarks. The Qwen license permits commercial use with attribution. As of 2026, it is available across Groq, Fireworks, Together, and DeepInfra, with price compression in progress as the model matures in the standard inference tier. For teams with East Asian language requirements at this parameter scale, it is the practical first choice. Pick Command R+ for teams already in the Cohere ecosystem who need its purpose-built RAG and tool-use architecture. Pick Mistral Large 2 for European multilingual workloads with competitive pricing across independent providers. Pick Qwen 3 72B when CJK multilingual quality and broad provider choice are both required.